The Effects of Normobaric and Hyperbaric Oxygenation on MRI T1, T2 and FLAIR Signal Intensities in Human Brain

Abstract

Dissolved oxygen has known paramagnetic effects in magnetic resonance imaging (MRI). The aim of this study was to compare the effects of normobaric oxygenation (NBO) and hyperbaric oxygenation (HBO) on human brain MRI signal intensities.

Baseline brain MRI was performed in 17 healthy subjects (mean age 27.8 ± 3.2). MRI was repeated after exposure to the NBO and HBO at different time points (0 min, 25 min, 50 min). T₁, T₂ and fluid attenuated inversion recovery (FLAIR) signal intensities of several intracranial structures were compared between NBO and HBO.

Increased T₁ signal intensities were observed in white and deep grey brain matter, cerebrospinal fluid (CSF), venous blood and vitreous body after exposure to NBO as well as to HBO compared to baseline (Dunnett’s test, p<0,05) without significant differences between both protocols. There was also no significant difference in T₂ signal intensities between HBO and NBO. FLAIR signal intensities were increased only in the vitreous body after NBO and HBO and FLAIR signal of caudate nucleus was decreased after NBO (Dunnett’s test, p<0,05). The statistically significant differences in FLAIR signal intensities were found between NBO and HBO (paired t-test, p<0,05) in most observed brain structures (paired t-test, p<0,05).

Our results show that NBO and HBO alters T₁ and FLAIR signal intensities of human brain. The differences between NBO and HBO are most pronounced in FLAIR imaging.