Prediction of 2 years-survival in patients with stage I and II non-small cell lung cancer utilizing F-18 FDG-PET/CT SUV quantification.

Authors

  • Natale Quartuccio Department of Radiological Sciences, Nuclear Medicine Unit, University of Messina, Messina, Italy
  • Angelina Cistaro
  • Alireza Mojtahedi
  • Piercarlo Fania
  • Pier Luigi Filosso
  • Alfredo Campenni
  • Umberto Ficola
  • Sergio Baldari

Abstract

Background. The purpose of the study was to evaluate the correlation between the maximum standardized uptake value (SUVmax), size of primary lung lesion, disease-free survival (DFS) and overall survival (OS) in patients with stage I and II non-small cell lung cancer (NSCLC) in 2 years follow-up.
Patients and methods. Forty-nine patients with stage I-II NSCLC were included in this study. Pre-surgical 2-deoxy-2-[18F]fluoro-D-glucose positron-emission tomography (18F-FDG PET/CT) study was performed for all patients. The relationship between SUVmax, tumour size and clinical outcome was measured. The cut-off value for SUVmax and tumour size with the best prognostic significance, probability of DFS and the correlation between SUVmax and the response to therapy were calculated.
Results. There was a statistically significant correlation between SUVmax and DFS (p = 0.029). The optimal cut-offs were 9.00 for SUVmax (p = 0.0013) and 30mm for tumour size (p = 0.0028). Patients with SUVmax > 9 and primary lesion size > 30 mm had an expected 2years-DFS of 37.5%, while this rose to 90% if the tumour was <30 mm and/or SUVmax was <9.
Conclusions. In stage I-II, SUVmax and tumour size might be helpful to identify the subgroup of patients with high chance for recurrence.

Author Biographies

Natale Quartuccio, Department of Radiological Sciences, Nuclear Medicine Unit, University of Messina, Messina, Italy

Angelina Cistaro

Alireza Mojtahedi

Piercarlo Fania

Pier Luigi Filosso

Alfredo Campenni

Umberto Ficola

Sergio Baldari

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Published

2013-08-27

How to Cite

Quartuccio, N., Cistaro, A., Mojtahedi, A., Fania, P., Filosso, P. L., Campenni, A., Ficola, U., & Baldari, S. (2013). Prediction of 2 years-survival in patients with stage I and II non-small cell lung cancer utilizing F-18 FDG-PET/CT SUV quantification. Radiology and Oncology, 47(3). Retrieved from https://www.radioloncol.com/index.php/ro/article/view/1020

Issue

Section

Nuclear medicine