Diagnosis and classification of spontaneously developed and radiation-induced murine haematopoietic neoplasms. The murine models for the research on the human haematopoietic neoplasms

Abstract

The Haematopathology Subcommittee of Mouse Models of Human Cancer Consortium (MMHC) proposed a classification that can be readily compared with the human WHO classification 2001 1 and appropriately delineates the diseases that occur in mice. The mouse lymphoid and nonlymphoid neoplasms develop spontaneously in certain strains and in genetically engineered mice (GEM) or follow induction with ionising radiation or chemical carcinogens or viruses. In the study, the haematopoietic neoplasms that developed in the three investigated mouse strains were identified according to the above classification. They can be useful as mouse models of human lymphoid and nonlymphoid haematopoietic neoplasms.