Are extracellular vesicles involved in phenotypic oncogenic transformation?

Authors

  • Eva Ogorevc Laboratory of biophysics Faculty of electrical engineering University of Ljubljana 1000 Ljubljana, Slovenia
  • Veronika Kralj-Iglič Faculty of health sciences University of Ljubljana 1000 Ljubljana, Slovenia
  • Peter Veranič Institute of cell biology, Medical faculty, University of Ljubljana 1000 Ljubljana, Slovenia

Abstract

Background. Cancer has traditionally been considered as a disease resulting from gene mutations. New findings in biology are challenging gene-centered explanations of cancer progression and redirecting them to the non-genetic
origins of tumorigenicity. It has become clear that intercellular communication plays a crucial role in cancer progression. Among the most intriguing ways of intercellular communication is that via extracellular vesicles (EVs). EVs are membrane structures released from various types of cells. After separation from the mother membrane, EVs become mobile and may travel from the extracellular space to blood and other body fluids.
Conclusions. Recently it has been shown that tumour cells are particularly prone to vesiculation and that tumour-derived
EVs can carry proteins, lipids and nucleic acids causative of cancer progression. The uptake of tumour-derived EVs by noncancerous cells can change their normal phenotype to cancerous. The suppression of vesiculation could slow down tumour growth and the spread of metastases. The purpose of this review is to highlight examples of EV-mediated cancer phenotypic transformation in the light of possible therapeutic applications.

Author Biographies

Eva Ogorevc, Laboratory of biophysics Faculty of electrical engineering University of Ljubljana 1000 Ljubljana, Slovenia

Veronika Kralj-Iglič, Faculty of health sciences University of Ljubljana 1000 Ljubljana, Slovenia

Peter Veranič, Institute of cell biology, Medical faculty, University of Ljubljana 1000 Ljubljana, Slovenia

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Published

2013-08-27

How to Cite

Ogorevc, E., Kralj-Iglič, V., & Veranič, P. (2013). Are extracellular vesicles involved in phenotypic oncogenic transformation?. Radiology and Oncology, 47(3). Retrieved from https://www.radioloncol.com/index.php/ro/article/view/1698

Issue

Section

Review