Osteoblastic bone metastases from renal cell carcinoma

  • Vladka Salapura
  • Irena Zupan
  • Boštjan Šeruga
  • Gordana Gašljević
  • Pavel Kavčič


In this article we describe a case of a 71-year old male patient with disseminated osteoblastic bone metastases from renal cell carcinoma (RCC), and present a short review of published literature reporting cases of osteoblastic bone metastases from RCC. RCC accounts for only 2-3% of all cancers.1 Due to its’ non-specific symptoms disease is often diagnosed in advanced stage. Disseminated RCC frequently produces bone metastases that are almost always highly destructive, hyper vascularized and purely osteolytic3. Our patient presented with thoracic pain aggravated by movement. He was diagnosed with predominantly osteoblastic bone metastases in the skeleton of thoracic and lumbar vertebra along with metastases in iliac bones, ribs, humerus and clavicles. Initially, origin of bone metastases was unknown, but later a small tumor in patient’s right kidney was identified. Microscopic evaluation of the open bone biopsy showed clear cell RCC with sarcomatoid differentiation. To our knowledge there are only six described cases of osteoblastic metastases of RCC in the literature so far.
How to Cite
Salapura, V., Zupan, I., Šeruga, B., Gašljević, G., & Kavčič, P. (2014). Osteoblastic bone metastases from renal cell carcinoma. Radiology and Oncology, 48(3). Retrieved from https://www.radioloncol.com/index.php/ro/article/view/1704