Xp 11. 2 translocation renal acrcinoma, in young adults; recently classified distinct subtype
Background XP11.2 renal translocation carcinomas are often encountred in pediatric group and are believed to be rather indolent, but are rare and more aggressive in young adults. They are slow growing, sometime without characteristic symptoms and their biologic behaviour is uncertain.
Case report We report first two cases of this type of tumor in Slovenia in adult young males with long and unusual history. Tumours were confirmed imunohistologically by positive reaction for CD10, P504S and TFE3.
Conclusions Prognosis of these tumours in young adults depends upon the stage. It seems that cysts, haematomas and necrosis around the kidney and tumor are often encountered. In advanced stage with lymph nodes involvement or distant metastases, the prognosis is poor. Surgery seems to be basic mode of therapy.