Segmentation of hepatic vessels from MRI images for planning of electroporation based treatments in the liver

  • Marija Marčan University of Ljubljana, Faculty of Electrical Engineering, Ljubljana
  • Denis Pavliha University of Ljubljana, Faculty of Electrical Engineering, Ljubljana
  • Maja Marolt Mušič Institute of Oncology Ljubljana
  • Igor Fučkan Clinical department for diagnostic and interventional radiology, Clinical Hospital “Dubrava”, Zagreb
  • Ratko Magjarević University of Zagreb, Fauclty of Electrical Engineering and Computing
  • Damijan Miklavčič University of Ljubljana, Faculty of Electrical Engineering, Ljubljana

Abstract

Introduction. Electroporation-based treatments rely on increasing the permeability of the cell membrane by exposing it to the electric field. To ensure that the whole tumor is covered by the sufficiently high electric field, accurate numerical models are built based on individual patient geometry. For the purpose of reconstruction of hepatic vessels from MRI images we searched for an optimal segmentation method that would meet the following initial criteria: identify major hepatic vessels, be robust and work with minimal user input.

Materials and methods. We tested the approaches based on vessel enhancement filtering, thresholding, and their combination in local thresholding. The methods were evaluated on a phantom and clinical data.

Results. Results show that thresholding based on variance minimization provides less error than the one based on entropy maximization. Best results were achieved by performing local thresholding of the original de-biased image in the regions of interest which were determined through previous vessel-enhancement filtering. In evaluation on clinical cases the optimal method scored in average sensitivity of 93.68%, average symmetric surface distance of 0.89 mm and Hausdorff distance of 4.04 mm.

Conclusions. The proposed method to segment hepatic vessels from MRI images based on local thresholding meets all the initial criteria necessary to use it in treatment planning of electroporation-based treatments: it identifies the major vessels, provides results with consistent accuracy and works completely automatically. Whether the achieved accuracy is acceptable or not for treatment-planning models remains to be verified through numerical modeling of effects of the segmentation error on the distribution of the electric field.
Published
2014-08-27
How to Cite
Marčan, M., Pavliha, D., Marolt Mušič, M., Fučkan, I., Magjarević, R., & Miklavčič, D. (2014). Segmentation of hepatic vessels from MRI images for planning of electroporation based treatments in the liver. Radiology and Oncology, 48(3). Retrieved from https://www.radioloncol.com/index.php/ro/article/view/2094
Section
Experimental radiology