LEVEL OF PEPSIN AND BILE ACIDS IN THE SALIVA OF PATIENTS WITH GLOTTIS T1 CARCINOMA

Authors

  • Maja Sereg Bahar

Abstract

ABSTRACT

Objectives. Gastroesophageal reflux is suspected to be an etiological factor for laryngeal cancer. The aim of this study was to establish using a non-invasive method whether laryngopharyngeal reflux (LPR) appears more often in patients with early glottic cancer than in control group.

Methods. We compared the pH, the level of bile acids, the total pepsin and the pepsin enzymatic activity in saliva in a group of 30 patients with T1 glottic carcinoma and a group of 34 healthy volunteers.

Results. The groups differed significantly in terms of levels of total pepsin and bile acids in a saliva sample.   Higher levels of total pepsin and bile acids were detected in the group of cancer patients. No significant impact of other known factors influencing laryngeal mucosa (e.g. smoking, alcohol consumption, and the presence of irritating substances at the workplace) on the results of saliva analysis was found.

Conclusions. A higher level of typical components of LPR in the saliva of patients with early glottic cancer than in the controls permits the possibility that LPR, especially biliary reflux has a role in the development of laryngeal carcinoma.

KEY WORDS:

laryngopharyngeal reflux, gastric acid, pepsin, bile acids, laryngeal carcinoma

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Published

2015-02-11

How to Cite

Sereg Bahar, M. (2015). LEVEL OF PEPSIN AND BILE ACIDS IN THE SALIVA OF PATIENTS WITH GLOTTIS T1 CARCINOMA. Radiology and Oncology, 49(1). Retrieved from https://www.radioloncol.com/index.php/ro/article/view/2102

Issue

Section

Clinical oncology