An image fusion system for estimating the therapeutic effects of radiofrequency ablation on hepatocellular carcinoma

Authors

  • Nobuyuki Toshikuni Kanazawa Medical University
  • Yasuhiro Matsue Kanazawa Medical University
  • Kazuaki Ozaki Kanazawa Medical University
  • Kaho Yamada Kanazawa Medical University
  • Nobuhiko Hayashi Kanazawa Medical University
  • Mutsumi Tsuchishima Kanazawa Medical University
  • Mikihiro Tsutsumi Kanazawa Medical University

Abstract

Background. During ultrasound-guided radiofrequency ablation (RFA) of hepatocellular carcinoma (HCC), high echoic areas due to RFA-induced microbubbles can help calculate the extent of ablation. However, these areas also decrease visualization of target tumors, making it difficult to assess whether they completely cover the tumors. To estimate the effects of RFA more precisely, we used an image fusion system (IFS).

Patients and methods. We enrolled patients with a single HCC who received RFA with or without the IFS. In the IFS group, we drew a spherical marker along the contour of a target tumor on reference images immediately after administering RFA so that the synchronized spherical marker represented the contour of the target tumor on real-time ultrasound images. When the high echoic area completely covered the marker, we considered the ablation to be complete. We compared outcomes between the IFS and control groups.

Results. We enrolled 25 patients and 20 controls, and the baseline characteristics were similar between the two groups. The complete ablation rates during the first RFA session were significantly higher in the IFS group compared with those in the control group (88.0% vs. 60.0%, P = 0.041). The number of RFA sessions was significantly smaller in the IFS group compared with that in the control group (1.1 ± 0.3 vs. 1.5 ± 0.7, P = 0.016).

Conclusions. Our study suggested that the IFS enables a more precise estimation of the effects of RFA on HCC, contributing to enhanced treatment efficacy and minimized patient burden.

Author Biographies

Nobuyuki Toshikuni, Kanazawa Medical University

Department of Hepatology

Yasuhiro Matsue, Kanazawa Medical University

Department of Hepatology

Kazuaki Ozaki, Kanazawa Medical University

Department of Hepatology

Kaho Yamada, Kanazawa Medical University

Department of Hepatology

Nobuhiko Hayashi, Kanazawa Medical University

Department of Hepatology

Mutsumi Tsuchishima, Kanazawa Medical University

Department of Hepatology

Mikihiro Tsutsumi, Kanazawa Medical University

Department of Hepatology

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Published

2017-09-10

How to Cite

Toshikuni, N., Matsue, Y., Ozaki, K., Yamada, K., Hayashi, N., Tsuchishima, M., & Tsutsumi, M. (2017). An image fusion system for estimating the therapeutic effects of radiofrequency ablation on hepatocellular carcinoma. Radiology and Oncology, 51(3). Retrieved from https://www.radioloncol.com/index.php/ro/article/view/2843

Issue

Section

Clinical oncology