Long-term survival of locally advanced stage III non-small cell lung cancer patients treated with chemoradiotherapy and perspectives for the treatment with immunotherapy

Authors

  • Martina Vrankar
  • Karmen Stanič, MD, PhD Deputy Editor

Abstract

Background. Standard treatment for patients with inoperable locally advanced non small cell lung cancer (NSCLC) is concurrent chemoradiotherapy (CCRT). Five-year overall survival rates range between 15 and 25%, while long term survival data are rarely reported.

Patients and methods. A total of 102 patients with stage III NSCLC treated between September 2005 and November 2010 with induction chemotherapy and CCRT were included in this long term survival analysis. All patients were tested for PD-L1 status and expression of PD-L1 was correlated with overall survival (OS), progression free survival (PFS) and toxicities.

Results. The median OS of all patients was 24.8 months (95% CI 18.7 to 31.0) with 10 year-survival rate of 11.2%. The median OS of patients with PD-L1 expression was 12.1 months (95% CI 0.1 to 26.2) and was significantly longer in patients with negative or unknown PD-L1 status, 25.2 months (95% CI 18.9 to 31.6), p=0.005. The median PFS of all patients was 16.4 months (95% CI 13.0 to 19.9). PFS of patients with PD-L1 expression was 10.1 months (95% CI 0.1 to 20.4) and in patients with negative or unknown  PD-L1 status was 17.9 months (95% CI 14.2 to 21.7), p=0.003.

Conclusions. 10-year overall survival of stage III NSCLC patients after CCRT is 11.2%. PFS and OS differ with regard to PD-L1 status and are significantly shorter for patients with PD-L1expression. New treatment with check-point inhibitors combined with RT therefore seems reasonable strategy to improve these results.

Author Biography

Martina Vrankar

Institute of Oncolgy, Radiotherapy department

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Published

2018-09-06

How to Cite

Vrankar, M., & Stanič, MD, PhD, K. (2018). Long-term survival of locally advanced stage III non-small cell lung cancer patients treated with chemoradiotherapy and perspectives for the treatment with immunotherapy. Radiology and Oncology, 52(3). Retrieved from https://www.radioloncol.com/index.php/ro/article/view/2960

Issue

Section

Clinical oncology