Can dynamic imaging, using 18F-FDG PET/CT and CT perfusion differentiate between benign and malignant pulmonary nodules?

  • Aleksander Marin M.D.
  • John T. Murchison
  • Kristopher M. Skwarski
  • Adriana A. S. Tavares
  • Alison Fletcher
  • William A. Wallace
  • Vladka Salapura
  • Edwin J.R. van Beek
  • Saeed Mirsadraee

Abstract

AIM

To derive and compare metabolic parameters relating to benign and malignant pulmonary nodules using dynamic 2-deoxy-2-[fluorine-18]fluoro-D-glucose (18F-FDG PET/CT), and nodule perfusion parameters derived through perfusion computed tomography (CT).

MATERIALS AND METHODS

Twenty patients with 21 pulmonary nodules incidentally detected on CT underwent a dynamic 18F-FDG PET/CT and a perfusion CT. The maximum standardised uptake value (SUVmax) was measured on conventional 18F-FDG PET/CT images. The influx constant (Ki) was calculated from the dynamic 18F-FDG PET/CT data using Patlak model. Arterial flow (AF) using the maximum slope model and blood volume (BV) using the Patlak plot method for each nodule were calculated from the perfusion CT data. All nodules were characterised as malignant or benign based on histopathology or 2 year follow up CT. All parameters were statistically compared between the two groups using the nonparametric Mann-Whitney test.

RESULTS

Twelve malignant and 9 benign lung nodules were analysed (median size 20.1 mm, 9–29 mm) in 21 patients (male/female=11/9; mean age±SD: 65.3±7.4; age range: 50–76 years). The average SUVmax values±SD of the benign and malignant nodules were 2.2±1.7 vs 7.0±4.5, respectively (p=0.0148). Average Ki values in benign and malignant nodules were 0.0057±0.0071 and 0.0230±0.0155 min-1, respectively (p=0.0311). Average BV for the benign and malignant nodules were 11.6857±6.7347 and 28.3400±15.9672 ml/100ml, respectively (p=0.0250). Average AF for the benign and malignant nodules were 74.4571±89.0321 and 89.200±49.8883 ml/100g/min, respectively (p=0.1613).

CONCLUSIONS

Dynamic 18F-FDG PET/CT and perfusion CT derived blood volume have similar capability to differentiate benign from malignant lung nodules.

Author Biographies

Aleksander Marin, M.D.

Edinburgh Imaging facility Queens Medical Research Institute, University of Edinburgh, Edinburgh, EH16 4TJ, United Kingdom

Faculty of Medicine, University of Ljubljana, Ljubljana, 1000, Slovenia

Radiology Department, University Hospital Llandough, Penlan Road, Penarth CF64 2XX, UK. Tel.: +44 29 20715563

John T. Murchison

Department of Radiology, Royal Infirmary of Edinburgh, Edinburgh, EH16 4SA, United Kingdom

Kristopher M. Skwarski

Department of Respiratory Medicine, Royal Infirmary of Edinburgh, Edinburgh, EH16 4SA, United Kingdom

Adriana A. S. Tavares

Edinburgh Imaging facility Queens Medical Research Institute, University of Edinburgh, Edinburgh, EH16 4TJ, United Kingdom

Alison Fletcher

Edinburgh Imaging facility Queens Medical Research Institute, University of Edinburgh, Edinburgh, EH16 4TJ, United Kingdom

William A. Wallace

Department of Pathology, Royal Infirmary of Edinburgh, Edinburgh, EH16 4SA, United Kingdom

Vladka Salapura

Faculty of Medicine, University of Ljubljana, Ljubljana, 1000, Slovenia

Edwin J.R. van Beek

Edinburgh Imaging facility Queens Medical Research Institute, University of Edinburgh, Edinburgh, EH16 4TJ, United Kingdom

Saeed Mirsadraee

National Heart and Lung Institute, Imperial College London, London, SW3 6LY, United Kingdom

Published
2021-07-28
How to Cite
Marin, A., Murchison , J., Skwarski, K., Tavares, A., Fletcher, A., Wallace, W., Salapura, V., van Beek , E., & Mirsadraee, S. (2021). Can dynamic imaging, using 18F-FDG PET/CT and CT perfusion differentiate between benign and malignant pulmonary nodules?. Radiology and Oncology, 55(3), 259-267. Retrieved from https://www.radioloncol.com/index.php/ro/article/view/3672
Section
Radiology