Diagnostic performance of ADC values for the Differentiation of Intrahepatic Cholangiocarcinoma from Gastrointestinal Adenocarcinoma Liver Metastases

ADC values for the Differentiation of Intrahepatic Cholangiocarcinoma from Gastrointestinal Adenocarcinoma Liver Metastases

Abstract

Background:

We aimed to investigate whether there is a difference between Intrahepatic cholangiocarcinomas (IHCC) and liver metastases of gastrointestinal system (GIS) adenocarcinoma in terms of ADC values.

Materials:

From January 2016 to January 2020, we retrospectively examined 64 consecutive patients with liver metastases due to gastrointestinal system adenocarcinomas and 13 consecutive  IHCC in our hospital’s medical records. After exclusions, fifty-three  patients with 53 liver metastases and 10 Intrahepatic cholangiocarcinoma ( IHCC) were included in our study . We divided the patients into two groups as IHCC and liver metastases of GIS adenocarcinoma . For mean apparent diffusion coefficient (ADC_mean) values, the region of interests (ROI) were placed in solid portions of the lesions.  ADC_mean values of groups were compared.

Results:

The mean age of IHCC group was 62,50±13,49 and mean age of metastases group was 61,15±9,18. ADC_mean values were significantly higher in the IHCC group compared to the metastatic group (p<0.001). ROC curves method showed high diagnostic accuracy(AUC=0.879) with cut-off value of <1178 x 10^-6 mm²/s for ADC_mean (Sensitivity=90,57, Specificity=70,0, PPV=94,1, NPV=58,3) in differentiating adenocarcinoma metastases from IHCC.

Conclusion:

Our study results suggest that ADC values have a potential role for differentiation between IHCC and GIS liver metastases which may be valuable for patient management.