CRANIOPHARYNGIOMA IN CHILDREN AND ADULTS

  • Mojca Jensterle Sever
  • Sončka Jazbinšek
  • Roman Bošnjak
  • Mara Popović
  • Lorna Zadravec Zaletel
  • Tina Vipotnik Vesnaver
  • Barbara Faganel Kotnik
  • Primož Kotnik University Medical Centre Ljubljana

Abstract

Childhood and adult-onset craniopharyngioma is a rare embryogenic tumor of the sellar, suprasellar, and parasellar region. Survival rates are high, however, tumor location and treatment sequalae including endocrine deficits, visual impairment, metabolic complications, cognitive and psycho-social deficits can significantly impair patient's quality of life. There is considerable controversy regarding the optimal management of craniopharyngiomas. Subtotal resection of the tumor followed by targeted irradiation to avoid further hypothalamic damage is currently indicated. Novel insights in the tumor’s molecular pathology present the possibility for targeted therapy possibly decreasing the rate and severity of treatment-associated morbidity. Craniopharyngioma should be seen as a chronic disease. To achieve optimal outcomes a multidisciplinary team of specialized neurosurgeons, neuro-radiologists, neuro-oncologists, pathologists and endocrinologists should be involved in the diagnosis, planning of the surgery and irradiation and long-term follow-up.

Published
2019-12-03
How to Cite
Jensterle Sever, M., Jazbinšek, S., Bošnjak, R., Popović, M., Zadravec Zaletel, L., Vipotnik Vesnaver, T., Faganel Kotnik, B., & Kotnik, P. (2019). CRANIOPHARYNGIOMA IN CHILDREN AND ADULTS. Radiology and Oncology, 53(4), 388-396. Retrieved from https://www.radioloncol.com/index.php/ro/article/view/3299
Section
Review